The fifth mainline entry in the Picross S series (and the sequel to Picross S4), Picross S5 features a new set of 300 standard nonogram puzzles (for Picross and Mega Picross modes), 5 multi-part "Clip Picross" puzzles, 30 Color Picross puzzles, and 5 Extra puzzles. In addition, this entry introduces optional "High Contrast" colors for Color Picross and tracks the total amount of time taken to complete all puzzles in each mode.